Longevity
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December 21, 2021EPA and DHA Attenuate Stress-Induced Vascular Senescence
This 12-week clinical trial of time-restricted but not energy-restricted eating in overweight and obese adults demonstrates that even a limited period of time-restricted eating (TRE) can improve weight and body composition in these individuals. It further establishes that TRE is a feasible approach to managing behaviors that impact glucose metabolism and risk for inflammatory and cardiometabolic disorders.
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August 30, 2021The Big Three in Nutritional Modulation of Immunosenescence
Cellular senescence is increasingly linked to biological aging of immune cells, which regulate the accumulation of senescent cells within tissues. This review examines aging processes that affect specific populations of immune cells from both adaptive and innate aspects of immunity. The authors propose three classes of nutraceuticals—phytonutrients, probiotics, and omega-3 fatty acids—for slowing and potentially reversing the progress of senescence in immune cells and, ultimately, reducing senescent cell burden.
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June 7, 2021Immune Aging May Drive Overall Aging
This strategic series of laboratory investigations clarifies that senescence of the immune system hastens and may precede systemic aging. Animals genetically modified for accelerated aging of white and red blood cells displayed immunosuppression and a senescence-associated secretory phenotype (SASP), which has been associated with ‘inflamm-aging’ and disequilibrium between immune offense and defense functions.
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May 3, 2021Evolving Research on Ameliorating Cell Senescence
This comprehensive review details pathways through which cells can become senescent, and emphasizes that not all are pathological. The authors describe ways of limiting the development of a senescence-associated secretory phenotype (SASP) as well as senolytic and senomorphic approaches that may potentially reduce senescent cell burden and related proinflammatory impacts.
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May 3, 2021Targeted Lifestyle Intervention May Help Reduce Epigenetic Age
This 8-week pilot study establishes that, in healthy aging males, a targeted lifestyle program can reduce epigenetic age as measured by the Horvath DNAmAge epigenetic clock. Compared to controls, participants receiving the intervention demonstrated a significant decrease in epigenetic age of 3.23 years.
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April 27, 2021Flavonoid Intake Associated with Top-Line Health Indicators
Vegetables and fruits are major dietary sources of flavonoids, and according to research cited
by the authors of this study, daily intakes of below 800 grams—around 1.75 pounds—of produce
is associated with increased mortality from cancer, cardiovascular causes, and overall causes of
death. -
March 29, 2021
Natural Senolytics May Aid Elimination of Senescent Cells
Does Himalayan Tartary Buckwheat affect glycemic response? Let’s find out …
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March 26, 2021
Quercetin Helps Target Pathways of Cell Aging and Survival
Does Himalayan Tartary Buckwheat affect glycemic response? Let’s find out …
