Publications
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The Sleep-Immune Crosstalk in Health and Disease
“Sleep and immunity are bidirectionally linked. Immune system activation alters sleep, and sleep in turn affects the innate and adaptive arm of our body’s defense system. “
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Time-Resolved Gene Expression Analysis Monitors the Regulation of Inflammatory Mediators and Attenuation of Adaptive Immune Response by Vitamin D
“Peripheral blood mononuclear cells (PBMCs) belong to the innate and adaptive immune system and are highly sensitive and responsive to changes in their systemic environment. In this study, we focused on the time course of transcriptional changes in freshly isolated human PBMCs 4, 8, 24 and 48 h after onset of stimulation with the active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3)..”
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Brain Health across the Lifespan: A Systematic Review on the Role of Omega-3 Fatty Acid Supplements
“Bearing in mind the scale of ageing populations and rising healthcare costs linked to poor brain health, omega supplementation could be a useful strategy for helping to augment dietary intakes and support brain health across the lifespan. Ongoing research is now needed using harmonious methodologies, supplement dosages, ratios and intervention periods to help formulate congruent conclusions.”
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Healthy Effects of Plant Polyphenols: Molecular Mechanisms
“The findings reported in the last decade are starting to help to decipher the complex relations between plant polyphenols and cell homeostatic systems including metabolic and redox equilibrium, proteostasis, and the inflammatory response, establishing an increasingly solid molecular basis for the healthy effects of these molecules. Taken together, the data currently available, though still incomplete, are providing a rationale for the possible use of natural polyphenols, or their molecular scaffolds, as nutraceuticals to contrast aging and to combat many associated pathologies.”
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The Pharmacological Potential of Rutin
“The contemporary scientific community has presently recognized flavonoids to be a unique class of therapeutic molecules due to their diverse therapeutic properties. Of these, rutin, also known as vitamin P or rutoside, has been explored for a number of pharmacological effects. Tea leaves, apples, and many more possess rutin as one of the active constituents. Today, rutin has been observed for its nutraceutical effect.”
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Associations of Omega-3 fatty acids with brain morphology and volume in cognitively healthy older adults: A narrative review
“Substantial research has aimed to discover the reasons why some people experience greater morphologic changes that produce undesirable consequences with aging and how it may be prevented. One possible explanation is diet, particularly fish consumption and the intake of omega-3 polyunsaturated fatty acids (omega 3) concentrated in fish oil.”
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Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021
“PUFAs display a plethora of biological activities at the molecular and cellular levels that result in effects on cell and tissue function linked to health outcomes and disease risk. Antioxidant and anti-inflammatory properties of omega-3 PUFAs are important and are recognized as contributing to reduced disease risk and severity (i.e., better health).”
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The prebiotic effects of omega-3 fatty acid supplementation: A six-week randomised intervention trial
“Dietary omega-3 alters gut microbiome composition and some of its cardiovascular effects appear to be potentially mediated by its effect on gut microbial fermentation products indicating that it may be a prebiotic nutrient.”
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Omega 3 Fatty Acid and Skin Diseases
“Because the incidences of inflammatory skin diseases and malignancies are currently increasing, future basic research and clinical trials for ω3 PUFAs in dermatology fields are expected give us a beneficial information for the daily clinical treatment for skin diseases.”
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Dietary supplementation of rutin and rutin-rich buckwheat elevates endogenous glucagon-like peptide 1 levels to facilitate glycemic control in type 2 diabetic mice
“In conclusion, rutin and related herbal materials are expected to provide health benefits due to their ability to modulate endogenous GLP-1 levels in T2D mice.”
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Polyphenols and Human Beings: From Epidemiology to Molecular Targets
“Dietary polyphenols have been associated with health benefits in the prevention of a range of degenerative and age-related diseases that constitute the major causes of death and incapacitation in developed countries.”
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Using an erythrocyte fatty acid fingerprint to predict risk of all-cause mortality: the Framingham Offspring Cohort
“The objective of this study was to compare a combination of RBC FA levels with standard risk factors for cardiovascular disease (CVD) in predicting risk of all-cause mortality.”
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The aging lung: Physiology, disease, and immunity
“Here, we review the molecular and cellular aspects of lung aging, local stress response pathways, and how the aging process predisposes to the pathogenesis of pulmonary disease. We place these insights into context of the COVID-19 pandemic and discuss how innate and adaptive immunity within the lung is altered with age.”
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Extraoral bitter taste receptors in health and disease
“Good medicine always tastes bitter.” This ancient Oriental wisdom may soon be verified with modern biology. Traditionally, bitter taste, one of five basic taste qualities, is thought to guide organisms to avoid harmful toxins and noxious substances and thus is critical to animal and human survival.”
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An aged immune system drives senescence and ageing of solid organs
“These data demonstrate that an aged, senescent immune system has a causal role in driving systemic ageing and therefore represents a key therapeutic target to extend healthy ageing.”
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Controlling the Resolution of Acute Inflammation: A New Genus of Dual Anti‐Inflammatory and Proresolving Mediators
“Taken together, these findings suggest that defective resolution mechanisms may underlie the inflammatory phenotypes that are believed to characterize many common human diseases.”
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Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration
“In the present study, LX and LX analogs were shown to have anti-inflammatory activity after oral administration in the zymosan A-induced peritonitis model.”
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Immunoresolvents signaling molecules at intersection between the brain and immune system
“The present brief review discusses evidence for the crosstalk between the nervous system and leukocytes in regulating SPM production.”
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Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection
“We provide evidence for a functional role of bioactive lipid mediators of the docosapentaenoic acid (DPA) metabolome in intestinal inflammation.”
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High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation
“…high content of anti-inflammatory and pro-resolving lipid mediators and their precursors may indicate their role in neonatal immunity and may be one of the reasons for the advantage of human milk over infant formula.”
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