Immune-Inflammatory Indices
Calculate your SII & SIRI
Use values from your most recent complete blood count (CBC) to calculate two research-based immune-inflammatory indices.
Four numbers already on your CBC, combined into the same indices used in immuno-metabolic research.
Enter your CBC results
Enter the absolute values shown on your laboratory report.
Often listed as ANC or "Neutrophils Abs."
Used as the denominator in both indices.
Contributes to SIRI only.
Same unit scale as the counts above.
Your results are calculated in your browser and are not stored or submitted through this calculator.
Your immune-inflammatory indices
SII
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Systemic Immune-Inflammation Index
Relative position: — within the reference framework configured for this tool.
SII is a calculated index that combines platelet, neutrophil, and lymphocyte counts. Researchers use SII to investigate relationships between circulating blood-cell populations and systemic immune-inflammatory activity.
SIRI
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Systemic Inflammation Response Index
Relative position: — within the reference framework configured for this tool.
SIRI combines neutrophil, monocyte, and lymphocyte counts into a single calculated index that has been used in research investigating systemic inflammatory and immune-related states.
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NLR Neutrophil-to-Lymphocyte Ratio — an additional CBC-derived index, shown for context.
Important
SII and SIRI are calculated research biomarkers and are not diagnostic tests. Results should not be used to diagnose, treat, cure, or prevent any disease, or to make medical decisions without guidance from a qualified healthcare professional. Individual results can be influenced by many factors, including acute illness and other physiological or clinical conditions.
A single result should be interpreted in the context of your overall health, laboratory results, and clinical history.
For healthcare professionals
The Dr. Bland Immunometabolic Signature Fullscript Journey Program
A ready-to-use clinical workflow built around SII, SIRI, and a curated biomarker panel.
Explore the Journey Program
The science, plainly
Understanding SII & SIRI
SII = Platelets × Neutrophils ÷ Lymphocytes
Platelets and neutrophils sit in the numerator; lymphocytes in the denominator. The index rises when platelet or neutrophil counts are relatively high compared with lymphocytes.
SIRI = Neutrophils × Monocytes ÷ Lymphocytes
SIRI swaps platelets for monocytes, weighting the innate-cell side of the count differently. The two indices are related but not interchangeable.
A complete blood count is already collected in routine care, so indices built from it are inexpensive and widely available. Combining several cell populations into one number is one way researchers summarise the balance between them, and that composite has been examined across a broad range of study populations. It remains a research measure, not a clinical test.
No single calculated index is designed to diagnose a condition on its own. SII and SIRI are research measures meant to be interpreted alongside your broader health picture, other lab results, and guidance from a qualified healthcare professional.
A single blood draw reflects one moment in time. Tracking SII and SIRI across multiple CBCs can offer more meaningful context than any one result viewed in isolation.
The spectrum positions shown in this tool use configurable reference boundaries that require Big Bold Health scientific review before publication. They are not established medical reference ranges.
The wider picture
Go beyond SII & SIRI
SII and SIRI can provide useful context from a standard CBC — but they are only part of the immuno-metabolic picture.
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Step one
Start with what you already have
Your CBC already contains the four values needed to calculate SII and SIRI.
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Step two
Look at patterns, not isolated markers
These indices combine several blood-cell measurements into broader research measures.
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Step three
Go beyond the CBC
A curated biomarker panel can add context around immune and metabolic health.
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Step four
Apply the framework clinically
A structured workflow puts the pattern to work — a step intended for healthcare professionals.
The CBC is just the beginning
The SII and SIRI calculations use information already contained in a standard CBC. The Immuno-Metabolic Program expands the view with a curated biomarker panel designed to help clinicians recognize relationships across immune and metabolic health.
For healthcare professionals
Go beyond single biomarkers
The Dr. Bland Immunometabolic Signature Fullscript Journey Program
This Journey translates Dr. Jeffrey Bland's work in functional medicine and systems biology into a ready-to-use clinical workflow, using the Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and a curated biomarker panel to help clinicians move beyond single markers and recognize meaningful immuno-metabolic patterns in their patients.
Learn how these patterns translate into personalized nutrition, lifestyle, and supplement recommendations — and how to bring this structured care pathway into your practice. Whether you want to sharpen clinical decision-making, deepen patient engagement, or streamline personalized care, the program offers a practical look at how this framework fits a working practice.
Explore the Journey ProgramAvailable through Fullscript. Opens in a new tab.
The program is a professional clinical workflow, not a diagnostic service, and not every patient requires every laboratory test. The calculator above remains educational and independent of it.
