Immune Rejuvenate®

HTB Activ™ is Big Bold Health's proprietary ingredient—a rare, heirloom strain of Himalayan Tartary Buckwheat, sourced and grown exclusively with US farming partners. Evolved in harsh, high-altitude climates, this plant developed an extraordinary concentration of natural defense compounds, including over 100 diverse polyphenols confirmed through clinical testing.

What sets HTB Activ™ apart is the process behind it. Seeds are grown in a living, regenerative soil microbiome, sprouted at peak nutritional potency, then gently dried and milled to preserve their bioavailability. The result is an ingredient unlike anything else on the market—one that Big Bold Health owns from farm to formula.

Sprouting is the moment a dormant seed comes to life, activating its plant intelligence in ways that become directly available to your body when consumed. As the seed sprouts, it ramps up production of protective compounds including polyphenols, flavonoids, phenolic acids, and antioxidants—reaching levels nearly 3x higher than unsprouted flour and over 15x higher than common buckwheat.

Through enzymatic activity, your body doesn't just receive more nutrients—it receives them in forms it can recognize, absorb, and utilize. Sprouting breaks down compounds into more bioavailable forms, enhances nutrient solubility, improves interaction with your digestive system, and reduces antinutrients that can interfere with absorption.

This article provides a more in-depth explanation.

Despite its name, buckwheat is classified as a pseudocereal (or "false grain") because it is used in the same culinary and nutritional ways as true grains. Buckwheat is actually a seed harvested from a broad-leafed flowering plant that is closely related to rhubarb and sorrel. Himalayan Tartary Buckwheat is an often overlooked ancient superfood that is biologically distinct, with an unusually rich polyphenol profile. Gluten-free, grain-free, and vegetarian.

This article discusses Himalayan Tartary Buckwheat further.

Our core products are built on HTB Activ™ as a foundational ingredient, each formulated to deliver it differently based on individual needs and lifestyle.

HTB Sprout Powder is pure HTB Activ™ with nothing added. Its ready-to-eat format supercharges everyday meals with a toasted, nutty flavor that pairs well with sweet and savory recipes.

Immunity Chews are a tasty on-the-go format with added vitamins and minerals formulated for immune support.

HTB Superfood is a whole-food shake mix that blends easily as a nutritious meal replacement.

HTB Flour is an organic, gluten-free flour alternative that adds polyphenol power to traditional recipes, made from HTB in its unsprouted form.

Immune Rejuvenate™ is a targeted polyphenol matrix and Microbiome Rejuvenate® is formulated for gut health—both available in convenient capsule form, an upgrade to your daily stack.

What you eat sends information your body acts on at a cellular level, the quality of those signals is instrumental. The immune system lives within every system of the body, when properly nourished, this directly shapes your healthspan.

HTB Activ™ delivers over 100 diverse polyphenols that build resilience from within, supporting:

• Vital organ integrity*
• Metabolic efficiency*
• Microbiome diversity*
• Cellular rejuvenation*
• Cognitive resilience*
• Inflammatory balance*

In this article, Dr. Jeff Bland discusses how the immune system powers longevity, and how food is the medicine that nourishes this connection.

In 2024, as part of the HTB Longevity Study, 50 healthy participants were given Immune Rejuvenate® for a period of 90 days. The study, which informed further research, revealed:

• 47% Reduction in Rate of Aging: Slowed the biological rate of aging —the definitive biomarker for functional healthspan
  
  22x Increase in the Activation of the CERK Pathway: The internal engine that regulates how your immune system ages and how long your cells live.
  
  6x Increase in Activation of COP9 Pathways: A critical regulator for brain cell health and coordinated immune signaling.

Outside of our own study, there is extensive research supporting this product:

1) Buckwheat bioactive compounds, their derived phenolic metabolites and their health benefits. Mol Nutr Food Res 2017. Giménez-Bastida JA et al. Source

2) Shaping a sustainable food future by rediscovering long-forgotten ancient grains. Plant Sci 2018. Cheng A. Source

3) Treasure from garden: Bioactive compounds of buckwheat. Food Chem 2021. Huda MN et al. Source

4) Rewiring of the seed metabolome during Tartary buckwheat domestication. Plant Biotechnol J 2022. Zhao H et al. Source

5) Chemical composition and health effects of Tartary buckwheat. Food Chem 2016. Zhu F. Source